Telomerase activity in gestational trophoblastic disease
نویسندگان
چکیده
منابع مشابه
Telomerase activity in gestational trophoblastic disease.
AIMS To investigate the pattern of telomerase activity in hydatidiform mole as compared with normal placenta and choriocarcinoma, and to determine the prognostic significance of telomerase activity in hydatidiform mole. METHODS Telomerase activity in 35 cases of hydatidiform mole, 35 normal placentas, one choriocarcinoma sample, and two choriocarcinoma cell lines (JAR, JEG3) was determined us...
متن کاملTelomerase activity in gestational trophoblastic disease and placental tissue from early and late human pregnancies.
BACKGROUND The aim of this study was to evaluate telomerase activity in tissue from cases of gestational trophoblastic disease (GTD) and in placental tissue from early and late human pregnancies. METHODS We used a telomeric repeat amplification protocol assay to measure telomerase activity in 132 tissue samples from normal early pregnancies, spontaneous abortions, normal late pregnancies, cas...
متن کاملGestational Trophoblastic Disease
In partial molar pregnancies, the trophoblast cells have three sets of chromosomes (triploid). Two sperm are believed to fertilise the ovum at the same time, leading to one set of maternal and two sets of paternal chromosomes. Around 10% of partial moles are tetraploid or mosaic in nature. There is usually evidence of fetal tissue or fetal blood cells in a partial molar pregnancy. An embryo may...
متن کاملGestational trophoblastic disease.
BACKGROUND Molar pregnancy represents a significant burden of disease on the spectrum of Gestational Trophoblastic Disease (GTD). The incidence appears to be quite high in South Asia. The objective of this study was to determine the frequency of GTD, and clinical presentation, management and outcome of patients with molar pregnancy. METHODS This retrospective, descriptive study was conducted ...
متن کاملGestational trophoblastic disease.
OBJECTIVE To provide standards for the diagnosis and treatment of patients with hydatidiform mole and gestational trophoblastic tumours (GTT). OPTIONS Prognostic factors useful for treatment decisions in GTT are defined with patients classified as low-, medium-, and high-risk groups. OUTCOMES Improved mortality and morbidity. EVIDENCE Evidence was gathered using Medline for relevant studi...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1999
ISSN: 0021-9746
DOI: 10.1136/jcp.52.8.588